The acknowledged impact of these PTMs on ATXN2’s functionality and SCA2 pathogenesis remains limited. In other polyQ diseases, multiple scientific tests proposed that proteolytic cleavage of polyQ proteins could Engage in an essential job in pathogenesis [36, 45]. Aligned with this strategy, the presence of the enriched 42 kDa fragment while https://greatm084ida7.wikitidings.com/user